Patients with severe insulin resistance lost significantly more weight as compared to insulin sensitive patients. The percentage of weight loss was independent of age, sex or BMI. Conclusion: Metformin is an effective drug to reduce weight in a naturalistic outpatient setting in insulin sensitive and insulin resistant overweight and obese patients.
Abstract Objective: The efficacy of metformin for the treatment of obesity has been evaluated in few clinical trials with inconclusive results. Twelve diet-treated NIDDM women with obesity were randomly given two dose levels mg or mg of metformin or placebo at for three consecutive days followed by a meal test on the third day on three occasions using a 3x3 Latin square design.
The number of sandwich canapes eaten in three consecutive minute periods beginning at hours was used to quantitate food intake, and the level of subjective hunger was rated just before the sandwich meal with a linear analogue hunger rating scale at after a 6-hour fast. The prior administration of metformin produced a reduction in calorie intake after each of the two doses of metformin treatment. The mg metformin dose had the most marked appetite suppressant action. Metformin can do more than help control your blood sugar — it may also help you lose stubborn pounds.
A long-term study published in the journal Diabetes Care that was conducted by the Diabetes Prevention Program concluded that the drug could serve as a treatment for excess body weight, although more studies are needed. The relationship between metformin and weight is unclear, but several theories provide possible explanations for weight fluctuations.
Reduced hunger is one documented side effect of metformin, according to the Mayo Clinic. For example, metformin may affect hunger cues. In one small study , 12 women with obesity and type 2 diabetes who were not taking insulin were randomly given two dose levels of metformin — milligrams mg or 1, mg — or a placebo three times a day for three days, with each participant going through the study three times so they had each dose and the placebo.
Participants received a meal test on each third day and rated their hunger level before eating. Researchers found that hunger levels in the metformin group were significantly lower, especially after the participants took the 1, mg dose compared with when they were taking the lower metformin dose or placebo. This subtle change in appetite could be responsible for a gradual decline in weight.
Having a frequent upset stomach or diarrhea, which is another side effect of the drug, can also affect your food intake.
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