Most heart attacks develop when a cholesterol-laden plaque in a coronary artery ruptures. Relatively small plaques, which produce only partial blockages, are the ones most likely to rupture. When they do, they attract platelets to their surface. Platelets are the tiny blood cells that trigger blood clotting. A clot, or thrombus, builds up on the ruptured plaque. As the clot grows, it blocks the artery.
If the blockage is complete, it deprives a portion of the heart muscle of oxygen. As a result, muscle cells die — and it's a heart attack. Aspirin helps by inhibiting platelets. Only a tiny amount is needed to inhibit all the platelets in the bloodstream; in fact, small amounts are better than high doses.
But since the clot grows minute by minute, time is of the essence. To find out how aspirin works fastest, researchers in Texas asked 12 volunteers to take a standard mg dose of aspirin in three different ways: by swallowing a tablet with 4 ounces of water, by chewing the tablet for 30 seconds before swallowing it, or by drinking 4 ounces of water with Alka-Seltzer.
Each subject tried all three methods on an empty stomach on different days. The scientists monitored blood levels of aspirin and its active ingredient, salicylate, at frequent intervals, and they also measured thromboxane B2 TxB2 , an indicator of platelet activation that drops as platelets are inhibited. By all three measurements, chewed aspirin worked fastest.
Similarly, it took 14 minutes for the chewed tablet to produce maximal platelet inhibition; it took Alka-Seltzer 16 minutes and the swallowed tablet 26 minutes. Aspirin can help prevent heart attacks in people with coronary artery disease and in those who have a higher than average risk. Only low dose, usually just 1 a day, is needed. But people who think they may be having an attack need an extra mg of aspirin, and they need it as quickly as possible.
For the best results, chew a single full-sized mg tablet, but don't use an enteric-coated tablet, which will act slowly even if chewed. And don't forget to call , then your doctor. It's a contemporary update on the old reminder to take two aspirin and call in the morning — and it's good advice to chew over.
Heart failure is manageable. Allergy alert: Aspirin may cause a severe allergic reaction, which may include: hives facial swelling asthma wheezing shock Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding.
Ask a doctor before use if stomach bleeding warning applies to you you have a history of stomach problems, such as heartburn you have high blood pressure, heart disease, liver cirrhosis, or kidney disease you are taking a diuretic you have asthma.
Ask a doctor or pharmacist before use if you are taking a prescription drug for gout diabetes arthritis. Stop use and ask a doctor if an allergic reaction occurs. Seek medical help right away you experience any of the following signs of stomach bleeding: feel faint vomit blood have bloody or black stool have stomach pain that does not get better pain gets worse or lasts more than 10 days redness or swelling is present new symptoms occur ringing in the ears or loss of hearing occurs.
If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. Manufactured by: Medline Industries, Inc.
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